Ghrelin and Obestatin in Human Neuroendocrine Tumors: Expression and Effect on Obestatin Levels after Food Intake

Ghrelin and obestatin in human neuroendocrine tumors: expression and effect on obestatin levels after food intake.

BACKGROUND Ghrelin and obestatin are derived from the same peptide hormone precursor and are mainly produced by the gastric mucosa. Ghrelin is involved in many biological processes, whereas the physiological function of obestatin needs further investigation. The aims of the present study were to establish the incidence of ghrelin- and obestatin-immunoreactive cells in a comprehensive panel of h...

Effects of Combined Training on the Levels of Obestatin, Ghrelin, and Insulin Resistance in Overweight Women

Background: The present quasi-experimental and field research was conducted to evaluate the effect of combined exercises on the levels of obestatin and ghrelin in overweight women. Methods: The study subjects consisted of 34 overweight women with a Mean±SD age of 30.29±4.66 years, a Mean±SD height of 165.11±5.56 cm, a Mean±SD weight of 74.64±7.33 kg, a Mean±SD body mass index of 27.35±1.74 kg/...

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilizat...

Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents.

Administration of ghrelin, an endogenous ligand for the GH secretagogue receptor 1a (GHSR 1a), induces potent stimulating effects on GH secretion and food intake. However, more than 7 yr after its discovery, the role of endogenous ghrelin remains elusive. Recently, a second peptide, obestatin, also generated from proteolytic cleavage of preproghrelin has been identified. This peptide inhibits f...

Ghrelin, Obestatin and Leptin in Childhood Obesity